The receptor tyrosine kinase FGFR4 negatively regulates NF-kappaB signaling.

ABSTRACT:

Background

NFκB signaling is of paramount importance in the regulation of apoptosis, proliferation, and inflammatory responses during human development and homeostasis, as well as in many human cancers. Receptor Tyrosine Kinases (RTKs), including the Fibroblast Growth Factor Receptors (FGFRs) are also important in development and disease. However, a direct relationship between growth factor signaling pathways and NFκB activation has not been previously described, although FGFs have been known to antagonize TNFα-induced apoptosis.

Methodology/principal findings

Here, we demonstrate an interaction between FGFR4 and IKKβ (Inhibitor of NFκB Kinase β subunit), an essential component in the NFκB pathway. This novel interaction was identified utilizing a yeast two-hybrid screen [1]

SUBMITTER: Drafahl KA 

PROVIDER: S-EPMC3008709 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature