ADAM and ADAMTS gene expression in native and wound healing human lens epithelial cells.

ABSTRACT:

Purpose

The ADAMs (a disintegrin and metalloproteinase) and the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin-like motifs) are extracellular proteases that mediate cellular interactions and cell signaling via the modulation of adhesion and the cleavage of cell surface protein ectodomains and extracellular matrix molecules. Gene expression profiling was undertaken to better understand the role of the ADAM and ADAMTS families in the clear native human lenses and following surgical injury with particular relevance to posterior capsule opacification.

Methods

To carry out profile analysis, the lens (t=0d) was dissected into three regions; anterior epithelia, equatorial region, and fiber cells. Capsular bag culture was undertaken as a means of assessing short-te

SUBMITTER: Hodgkinson LM 

PROVIDER: S-EPMC3008711 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature