The transcriptional response in human umbilical vein endothelial cells exposed to insulin: a dynamic gene expression approach.

ABSTRACT:

Background

In diabetes chronic hyperinsulinemia contributes to the instability of the atherosclerotic plaque and stimulates cellular proliferation through the activation of the MAP kinases, which in turn regulate cellular proliferation. However, it is not known whether insulin itself could increase the transcription of specific genes for cellular proliferation in the endothelium. Hence, the characterization of transcriptional modifications in endothelium is an important step for a better understanding of the mechanism of insulin action and the relationship between endothelial cell dysfunction and insulin resistance.

Methodology and principal findings

The transcriptional response of endothelial cells in the 440 minutes following insulin stimulation was monitored using microar

SUBMITTER: Di Camillo B 

PROVIDER: S-EPMC3008714 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature