Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study.

ABSTRACT:

Purpose

To present genome-wide association analyses of genotypic and environmental risks on age-related macular degeneration (AMD) using 593 subjects from the age-related eye disease study (AREDS), after adjusting for population stratification and including questionable controls.

Methods

Single nucleotide polymorphism (SNP) associations with AMD for the non-Hispanic white population were investigated using a log-additive model after adjusting for population stratification. Replication of possible SNP-disease association was performed by genotyping an independent group of 444 AMD case and 300 control subjects. Logistic regression models were used to assess interaction effects between smoking and SNPs associated with AMD. Independent genetic risk effects among the disease-asso

SUBMITTER: Ryu E 

PROVIDER: S-EPMC3008720 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature