The bacterial intimins and invasins: a large and novel family of secreted proteins.

ABSTRACT:

Background

Gram-negative bacteria have developed a limited repertoire of solutions for secreting proteins from the cytoplasmic compartment to the exterior of the cell. Amongst the spectrum of secreted proteins are the intimins and invasins (the Int/Inv family; TC# 1.B.54) which are characterized by an N-terminal β-barrel domain and a C-terminal surface localized passenger domain. Despite the important role played by members of this family in diseases mediated by several species of the Enterobacteriaceae, there has been little appreciation for the distribution and diversity of these proteins amongst Gram-negative bacteria. Furthermore, there is little understanding of the molecular events governing secretion of these proteins to the extracellular milieu.

Principal findings

In

SUBMITTER: Tsai JC 

PROVIDER: S-EPMC3008723 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature