Association between a high-risk autism locus on 5p14 and social communication spectrum phenotypes in the general population.

ABSTRACT:

Objective

Recent genome-wide analysis identified a genetic variant on 5p14.1 (rs4307059), which is associated with risk for autism spectrum disorder. This study investigated whether rs4307059 also operates as a quantitative trait locus underlying a broader autism phenotype in the general population, focusing specifically on the social communication aspect of the spectrum.

Method

Study participants were 7,313 children from the Avon Longitudinal Study of Parents and Children. Single-trait and joint-trait genotype associations were investigated for 29 measures related to language and communication, verbal intelligence, social interaction, and behavioral adjustment, assessed between ages 3 and 12 years. Analyses were performed in one-sided or directed mode and adjusted for multi

SUBMITTER: St Pourcain B 

PROVIDER: S-EPMC3008767 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature