The Transmembrane Domain C of AMPA Receptors is Critically Involved in Receptor Function and Modulation.

ABSTRACT: Ionotropic glutamate receptors are major players in synaptic transmission and are critically involved in many cognitive events. Although receptors of different subfamilies serve different functions, they all show a conserved domain topology. For most of these domains, structure-function relationships have been established and are well understood. However, up to date the role of the transmembrane domain C in receptor function has been investigated only poorly. We have constructed a series of receptor chimeras and point mutants designed to shed light on the structural and/or functional importance of this domain. We here present evidence that the role of transmembrane domain C exceeds that of a mere scaffolding domain and that several amino acid residues located within the domain are crucial

SUBMITTER: Terhag J 

PROVIDER: S-EPMC3009476 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature