An ontology-based search engine for protein-protein interactions.

ABSTRACT:

Background

Keyword matching or ID matching is the most common searching method in a large database of protein-protein interactions. They are purely syntactic methods, and retrieve the records in the database that contain a keyword or ID specified in a query. Such syntactic search methods often retrieve too few search results or no results despite many potential matches present in the database.

Results

We have developed a new method for representing protein-protein interactions and the Gene Ontology (GO) using modified Gödel numbers. This representation is hidden from users but enables a search engine using the representation to efficiently search protein-protein interactions in a biologically meaningful way. Given a query protein with optional search conditions expressed in

SUBMITTER: Park B 

PROVIDER: S-EPMC3009494 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature