Using genomic signatures for HIV-1 sub-typing.

ABSTRACT:

Background

Human Immunodeficiency Virus type 1 (HIV-1), the causative agent of Acquired Immune Deficiency Syndrome (AIDS), exhibits very high genetic diversity with different variants or subtypes prevalent in different parts of the world. Proper classification of the HIV-1 subtypes, displaying differential infectivity, plays a major role in monitoring the epidemic and is also a critical component for effective treatment strategy. The existing methods to classify HIV-1 sequence subtypes, based on phylogenetic analysis focusing only on specific genes/regions, have shown inconsistencies as they lack the capability to analyse whole genome variations. Several isolates are left unclassified due to unresolved sub-typing. It is apparent that classification of subtypes based on complete gen

SUBMITTER: Pandit A 

PROVIDER: S-EPMC3009497 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature