Predicting the protein-protein interactions using primary structures with predicted protein surface.

ABSTRACT:

Background

Many biological functions involve various protein-protein interactions (PPIs). Elucidating such interactions is crucial for understanding general principles of cellular systems. Previous studies have shown the potential of predicting PPIs based on only sequence information. Compared to approaches that require other auxiliary information, these sequence-based approaches can be applied to a broader range of applications.

Results

This study presents a novel sequence-based method based on the assumption that protein-protein interactions are more related to amino acids at the surface than those at the core. The present method considers surface information and maintains the advantage of relying on only sequence data by including an accessible surface area (ASA) predicto

SUBMITTER: Chang DT 

PROVIDER: S-EPMC3009501 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature