Comparison of PGH2 binding site in prostaglandin synthases.

ABSTRACT:

Background

Prostaglandin H2 (PGH2) is a common precursor for the synthesis of five different Prostanoids via specific Prostanoid Synthases. The binding of this substrate with these Synthases is not properly understood. Moreover, currently no crystal structure of complexes bound with PGH2 has been reported. Hence, understanding the interactions of PGH2 and characterizing its binding sites in these synthases is crucial for developing novel therapeutics based on these proteins as targets.

Results

Shape and physico-chemical properties of the PGH2 binding sites of the four prostanoid synthases were analyzed and compared in order to understand the molecular basis of the specificity. This study provides models with predicted pockets for the binding of PGH2 with PGD, PGE, PGF and PG

SUBMITTER: Paragi-Vedanthi P 

PROVIDER: S-EPMC3009524 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature