Phase-locked signals elucidate circuit architecture of an oscillatory pathway.

ABSTRACT: This paper introduces the concept of phase-locking analysis of oscillatory cellular signaling systems to elucidate biochemical circuit architecture. Phase-locking is a physical phenomenon that refers to a response mode in which system output is synchronized to a periodic stimulus; in some instances, the number of responses can be fewer than the number of inputs, indicative of skipped beats. While the observation of phase-locking alone is largely independent of detailed mechanism, we find that the properties of phase-locking are useful for discriminating circuit architectures because they reflect not only the activation but also the recovery characteristics of biochemical circuits. Here, this principle is demonstrated for analysis of a G-protein coupled receptor system, the M3 muscarinic re

SUBMITTER: Jovic A 

PROVIDER: S-EPMC3009597 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature