Widespread compensatory evolution conserves DNA-encoded nucleosome organization in yeast.

ABSTRACT: Evolution maintains organismal fitness by preserving genomic information. This is widely assumed to involve conservation of specific genomic loci among species. Many genomic encodings are now recognized to integrate small contributions from multiple genomic positions into quantitative dispersed codes, but the evolutionary dynamics of such codes are still poorly understood. Here we show that in yeast, sequences that quantitatively affect nucleosome occupancy evolve under compensatory dynamics that maintain heterogeneous levels of A+T content through spatially coupled A/T-losing and A/T-gaining substitutions. Evolutionary modeling combined with data on yeast polymorphisms supports the idea that these substitution dynamics are a consequence of weak selection. This shows that compensatory evol

SUBMITTER: Kenigsberg E 

PROVIDER: S-EPMC3009600 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature