Gene expression profile analysis of genes in rat hippocampus from antidepressant treated rats using DNA microarray.

ABSTRACT:

Background

The molecular and biological mechanisms by which many antidepressants function are based on the monoamine depletion hypothesis. However, the entire cascade of mechanisms responsible for the therapeutic effect of antidepressants has not yet been elucidated.

Results

We used a genome-wide microarray system containing 30,000 clones to evaluate total RNA that had been isolated from the brains of treated rats to identify the genes involved in the therapeutic mechanisms of various antidepressants, a tricyclic antidepressant (imipramine). a selective serotonin reuptake inhibitor (fluoxetine), a monoamine oxidase inhibitor (phenelzine) and psychoactive herbal extracts of Nelumbinis Semen (NS). To confirm the differential expression of the identified genes, we analyzed the

SUBMITTER: Lee JH 

PROVIDER: S-EPMC3009642 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature