Plasma protein profiling reveals protein clusters related to BMI and insulin levels in middle-aged overweight subjects.

ABSTRACT:

Background

Biomarkers that allow detection of the onset of disease are of high interest since early detection would allow intervening with lifestyle and nutritional changes before the disease is manifested and pharmacological therapy is required. Our study aimed to improve the phenotypic characterization of overweight but apparently healthy subjects and to identify new candidate profiles for early biomarkers of obesity-related diseases such as cardiovascular disease and type 2 diabetes.

Methodology/principal findings

In a population of 56 healthy, middle-aged overweight subjects Body Mass Index (BMI), fasting concentration of 124 plasma proteins and insulin were determined. The plasma proteins are implicated in chronic diseases, inflammation, endothelial function and metabol

SUBMITTER: van Dijk SJ 

PROVIDER: S-EPMC3009718 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature