Tiling array analysis of UV treated Escherichia coli predicts novel differentially expressed small peptides.

ABSTRACT:

Background

Despite comprehensive investigation, the Escherichia coli SOS response system is not yet fully understood. We have applied custom designed whole genome tiling arrays to measure UV invoked transcriptional changes in E. coli. This study provides a more complete insight into the transcriptome and the UV irradiation response of this microorganism.

Results

We detected a number of novel differentially expressed transcripts in addition to the expected SOS response genes (such as sulA, recN, uvrA, lexA, umuC and umuD) in the UV treated cells. Several of the differentially expressed transcripts might play important roles in regulation of the cellular response to UV damage. We have predicted 23 novel small peptides from our set of detected non-gene transcripts. Further, thr

SUBMITTER: Thomassen GO 

PROVIDER: S-EPMC3009722 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature