Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway.

ABSTRACT: Epidemiologic studies show a high incidence of cancer in shift workers, suggesting a possible relationship between circadian rhythms and tumorigenesis. However, the precise molecular mechanism played by circadian rhythms in tumor progression is not known. To identify the possible mechanisms underlying tumor progression related to circadian rhythms, we set up nude mouse xenograft models. HeLa cells were injected in nude mice and nude mice were moved to two different cases, one case is exposed to a 24-hour light cycle (L/L), the other is a more "normal" 12-hour light/dark cycle (L/D). We found a significant increase in tumor volume in the L/L group compared with the L/D group. In addition, tumor microvessels and stroma were strongly increased in L/L mice. Although there was a hypervasculariz

SUBMITTER: Yasuniwa Y 

PROVIDER: S-EPMC3009728 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature