An intact centrosome is required for the maintenance of polarization during directional cell migration.

ABSTRACT:

Background

Establishing and maintaining polarization is critical during cell migration. It is known that the centrosome contains numerous proteins whose roles of organizing the microtubule network range include nucleation, stabilization and severing. It is not known whether the centrosome is necessary to maintain polarization. Due to its role as the microtubule organizing center, we hypothesize that the centrosome is necessary to maintain polarization in a migrating cell. Although there have been implications of its role in cell migration, there is no direct study of the centrosome's role in maintaining polarization. In this study we ablate the centrosome by intracellular laser irradiation to understand the role of the centrosome in two vastly different cell types, human osteosarco

SUBMITTER: Wakida NM 

PROVIDER: S-EPMC3009746 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature