QM/MM studies of monozinc ?-lactamase CphA suggest that the crystal structure of an enzyme-intermediate complex represents a minor pathway.
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ABSTRACT:
SUBMITTER: Wu S
PROVIDER: S-EPMC3009838 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
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QM/MM studies of monozinc β-lactamase CphA suggest that the crystal structure of an enzyme-intermediate complex represents a minor pathway.
Wu Shanshan S Xu Dingguo D Guo Hua H
Journal of the American Chemical Society 20101207 51
QM/MM studies of the hydrolysis of a β-lactam antibiotic molecule (biapenem) catalyzed by a monozinc β-lactamase (CphA) have revealed the complete reaction mechanism and shown that an experimentally determined enzyme-intermediate complex is a stable intermediate or product in a minor pathway. ...[more]
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