CD300 heterocomplexes, a new and family-restricted mechanism for myeloid cell signaling regulation.

ABSTRACT: The CD300 family of myeloid immunoglobulin receptors includes activating (CD300b, CD300e) and inhibitory members (CD300a, CD300f), as well as molecules of uncertain function presenting a negative charge within their transmembrane domain (CD300c, CD300d). In this paper, we establish that CD300c is a functional immune receptor able to deliver activating signals upon ligation in RBL-2H3 mast cells. CD300c signaling is partially mediated by a direct association with the immune receptor tyrosine-based activation motif-bearing adaptor FcεRγ. The existence of complementary transmembrane-charged residues in certain CD300 receptors suggested the formation of heterodimers within this family. Indeed, we proved the interaction between CD300b and CD300c in transfected COS-7 cells and demonstrated that

SUBMITTER: Martinez-Barriocanal A 

PROVIDER: S-EPMC3009906 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature