Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron.

ABSTRACT: The existence of a local renin angiotensin system (RAS) of the kidney has been established. Angiotensinogen (AGT), renin, angiotensin-converting enzyme (ACE), angiotensin receptors, and high concentrations of luminal angiotensin II have been found in the proximal tubule. Although functional data have documented the relevance of a local RAS, the dualism between biosynthesis and endocytotic uptake of its components and their cellular processing has been incompletely understood. To resolve this, we have selectively analyzed their distribution, endocytosis, transcytosis, and biosynthesis in the proximal tubule. The presence of immunoreactive AGT, restricted to the early proximal tubule, was due to its retrieval from the ultrafiltrate and storage in endosomal and lysosomal compartments. Cellula

SUBMITTER: Pohl M 

PROVIDER: S-EPMC3009920 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature