Kzp controls canonical Wnt8 signaling to modulate dorsoventral patterning during zebrafish gastrulation.

ABSTRACT: During vertebrate embryonic development, the body axis formation requires the action of Wnt signals and their antagonists. Zygotic canonical wnt8 expression appears exclusively at the ventrolateral margin and mediates Wnt/β-catenin activities to promote posterior and ventral cell fate. However, the mechanisms involved in the initiation of zygotic wnt8 signals are poorly understood. Here, we identify a novel, maternally derived transcription factor, Kzp (Kaiso zinc finger-containing protein), as an important determinant for the initiation of zygotic Wnt signals in zebrafish. Kzp is a DNA-binding transcription factor that recognizes specific consensus DNA sequences, 5'-(t/a/g)t(a/t/g)nctgcca-3', through zinc fingers and controls the initiation of zygotic wnt8 expression by directly binding t

SUBMITTER: Yao S 

PROVIDER: S-EPMC3009934 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature