Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain.

ABSTRACT:

Background

The CCR2/CCL2 system has been identified as a regulator in the pathogenesis of neuropathy-induced pain. However, CCR2 target validation in analgesia and the mechanism underlying antinociception produced by CCR2 antagonists remains poorly understood. In this study, in vitro and in vivo pharmacological approaches using a novel CCR2 antagonist, AZ889, strengthened the hypothesis of a CCR2 contribution to neuropathic pain and provided confidence over the possibilities to treat neuropathic pain with CCR2 antagonists.

Results

We provided evidence that dorsal root ganglia (DRG) cells harvested from CCI animals responded to stimulation by CCL2 with a concentration-dependent calcium rise involving PLC-dependent internal stores. This response was associated with an increase

SUBMITTER: Serrano A 

PROVIDER: S-EPMC3009975 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature