Genetic interactions reveal the evolutionary trajectories of duplicate genes.

ABSTRACT: The characterization of functional redundancy and divergence between duplicate genes is an important step in understanding the evolution of genetic systems. Large-scale genetic network analysis in Saccharomyces cerevisiae provides a powerful perspective for addressing these questions through quantitative measurements of genetic interactions between pairs of duplicated genes, and more generally, through the study of genome-wide genetic interaction profiles associated with duplicated genes. We show that duplicate genes exhibit fewer genetic interactions than other genes because they tend to buffer one another functionally, whereas observed interactions are non-overlapping and reflect their divergent roles. We also show that duplicate gene pairs are highly imbalanced in their number of geneti

SUBMITTER: VanderSluis B 

PROVIDER: S-EPMC3010121 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature