Interleukin-17-dependent autoimmunity to collagen type V in atherosclerosis.

ABSTRACT:

Rationale

Considerable evidence shows atherosclerosis to be a chronic inflammatory disease in which immunity to self-antigens contributes to disease progression. We recently identified the collagen type V [col(V)] α1(V) chain as a key autoantigen driving the Th17-dependent cellular immunity underlying another chronic inflammatory disease, obliterative bronchiolitis. Because specific induction of α1(V) chains has previously been reported in human atheromas, we postulated involvement of col(V) autoimmunity in atherosclerosis.

Objective

To determine whether col(V) autoimmunity may be involved in the pathogenesis of atherosclerosis.

Methods and results

Here, we demonstrate Th17-dependent anti-col(V) immunity to be characteristic of atherosclerosis in human coronary artery

SUBMITTER: Dart ML 

PROVIDER: S-EPMC3010213 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature