Lack of association between thiazolidinediones and macular edema in type 2 diabetes: the ACCORD eye substudy.

ABSTRACT:

Objective

To assess the cross-sectional association of thiazolidinediones with diabetic macular edema (DME).

Methods

The cross-sectional association of DME and visual acuity with thiazolidinediones was examined by means of baseline fundus photographs and visual acuity measurements from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Visual acuity was assessed in 9690 participants in the ACCORD trial, and 3473 of these participants had fundus photographs that were centrally read in a standardized fashion by masked graders to assess DME and retinopathy from October 23, 2003, to March 10, 2006.

Results

Among the subsample, 695 (20.0%) people had used thiazolidinediones, whereas 217 (6.2%) people had DME. Thiazolidinedione use was not associated with

SUBMITTER: Ambrosius WT 

PROVIDER: S-EPMC3010554 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature