Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2.

ABSTRACT:

Background and purpose

Hydrogen sulphide (H(2)S), considered as a novel gas transmitter, is produced endogenously in mammalian tissue from L-cysteine by two enzymes, cystathionine β-synthase and cystathionine γ-lyase. Recently, it has been reported that H(2)S contributes to the local and systemic inflammation in several experimental animal models. We conducted this study to investigate on the signalling involved in H(2)S-induced inflammation.

Experimental approach

L-cysteine or sodium hydrogen sulphide (NaHS) was injected into the mouse hind paw and oedema formation was evaluated for 60 min. In order to investigate H(2)S-induced oedema formation, we used 5-HT and histamine receptor antagonists, and inhibitors of K(ATP) channels or arachidonic acid cascade. Prostaglandin leve

SUBMITTER: di Villa Bianca Rd 

PROVIDER: S-EPMC3010586 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature