CD8+ T cells negatively regulate IL-4-dependent, IgG1-dominant posttransplant alloantibody production.

ABSTRACT: We have previously reported that CD8(+) T cells significantly influence Ab production based on the observation that posttransplant alloantibody levels in CD8-deficient murine hepatocyte transplant recipients are markedly enhanced. However, the precise mechanisms contributing to enhanced alloantibody production in the absence of CD8(+) T cells is not understood. We hypothesized that alloactivated CD8(+) T cells inhibit Ab production by skewing toward a proinflammatory cytokine profile, whereas when these cells are absent, an anti-inflammatory cytokine profile shifts the alloimmune response toward alloantibody production. To investigate this possibility, alloantibody isotype profiles were examined in CD8-deficient and wild-type hepatocyte recipients. We found that IgG1 (IL-4-dependent isotyp

SUBMITTER: Zimmerer JM 

PROVIDER: S-EPMC3010751 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature