SNCA variant associated with Parkinson disease and plasma alpha-synuclein level.

ABSTRACT:

Background

A functional repeat polymorphism in the SNCA promoter (REP1) conveys susceptibility for Parkinson disease (PD). There is also increasing evidence that single-nucleotide polymorphisms (SNPs) elsewhere in the gene are associated with PD risk.

Objectives

To further explore the association of common SNCA SNPs with PD susceptibility, to determine whether evidence of allelic heterogeneity exists, and to examine the correlation between PD-associated variants and plasma α-synuclein levels.

Design

Two-tiered analysis.

Setting

Academic research.

Patients

Patients and control subjects from the NeuroGenetics Research Consortium.

Main outcome measures

We performed a 2-tiered analysis of 1956 patients with PD and 2112 controls from the NeuroGenetics

SUBMITTER: Mata IF 

PROVIDER: S-EPMC3010848 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature