In vitro modulation of cartilage shape plasticity by biochemical regulation of matrix remodeling.

ABSTRACT: With consideration of the need for cartilage grafts of specific sizes and shapes in orthopedics and other fields, immature cartilage explants and grafts have recently been molded in vitro and in vivo. Nonsurgical correction of cartilage deformities and malformations often uses mechanical stimuli and further demonstrates the plasticity of cartilage shape. Cartilage shape plasticity appears to diminish with maturation, coincident with changes in matrix composition. This study's objectives were to characterize shape plasticity of articular cartilage from immature and mature bovines and test whether altering proteoglycan and collagen (COL) remodeling modulates shape plasticity in vitro. Cartilage explants were analyzed fresh on day 0 or after 14 days of culture in the presence of β-D-xyloside

SUBMITTER: Williams GM 

PROVIDER: S-EPMC3011909 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature