MethVisual - visualization and exploratory statistical analysis of DNA methylation profiles from bisulfite sequencing.

ABSTRACT:

Background

Exploration of DNA methylation and its impact on various regulatory mechanisms has become a very active field of research. Simultaneously there is an arising need for tools to process and analyse the data together with statistical investigation and visualisation.

Findings

MethVisual is a new application that enables exploratory analysis and intuitive visualization of DNA methylation data as is typically generated by bisulfite sequencing. The package allows the import of DNA methylation sequences, aligns them and performs quality control comparison. It comprises basic analysis steps as lollipop visualization, co-occurrence display of methylation of neighbouring and distant CpG sites, summary statistics on methylation status, clustering and correspondence analysis.

SUBMITTER: Zackay A 

PROVIDER: S-EPMC3012040 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature