Phenotypic characterization of a genetically diverse panel of mice for behavioral despair and anxiety.

ABSTRACT:

Background

Animal models of human behavioral endophenotypes, such as the Tail Suspension Test (TST) and the Open Field assay (OF), have proven to be essential tools in revealing the genetics and mechanisms of psychiatric diseases. As in the human disorders they model, the measurements generated in these behavioral assays are significantly impacted by the genetic background of the animals tested. In order to better understand the strain-dependent phenotypic variability endemic to this type of work, and better inform future studies that rely on the data generated by these models, we phenotyped 33 inbred mouse strains for immobility in the TST, a mouse model of behavioral despair, and for activity in the OF, a model of general anxiety and locomotor activity.

Results

We identifi

SUBMITTER: Miller BH 

PROVIDER: S-EPMC3012073 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature