A complete analysis of HA and NA genes of influenza A viruses.

ABSTRACT:

Background

More and more nucleotide sequences of type A influenza virus are available in public databases. Although these sequences have been the focus of many molecular epidemiological and phylogenetic analyses, most studies only deal with a few representative sequences. In this paper, we present a complete analysis of all Haemagglutinin (HA) and Neuraminidase (NA) gene sequences available to allow large scale analyses of the evolution and epidemiology of type A influenza.

Methodology/principal findings

This paper describes an analysis and complete classification of all HA and NA gene sequences available in public databases using multivariate and phylogenetic methods.

Conclusions/significance

We analyzed 18,975 HA sequences and divided them into 280 subgroups accordi

SUBMITTER: Shi W 

PROVIDER: S-EPMC3012125 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature