P-selectin glycoprotein ligand-1 deficiency is protective against obesity-related insulin resistance.

ABSTRACT:

Objective

An inflammatory process is involved in the mechanism of obesity-related insulin resistance. Recent studies indicate that monocyte chemoattractant protein-1 (MCP-1) is a major chemokine that promotes monocyte infiltration into adipose tissues; however, the adhesion pathway in adipose tissues remains unclear. We aimed to clarify the adhesion molecules that mediate monocyte infiltration into adipose tissue.

Research design and methods

We used a DNA microarray to compare the gene expression profiles in epididymal white adipose tissues (eWAT) between db/db mice and C57/BL6 mice each fed a high-fat diet (HFD) or a low-fat diet (LFD). We investigated the change of insulin resistance and inflammation in eWAT in P-selectin glycoprotein ligand-1 (PSGL-1) homozygous knockout

SUBMITTER: Sato C 

PROVIDER: S-EPMC3012171 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature