Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study.

ABSTRACT:

Objective

To assess whether recently discovered genetic loci associated with hyperglycemia also predict long-term changes in glycemic traits.

Research design and methods

Sixteen fasting glucose-raising loci were genotyped in middle-aged adults from the Gene x Lifestyle interactions And Complex traits Involved in Elevated disease Risk (GLACIER) Study, a population-based prospective cohort study from northern Sweden. Genotypes were tested for association with baseline fasting and 2-h postchallenge glycemia (N = 16,330), and for changes in these glycemic traits during a 10-year follow-up period (N = 4,059).

Results

Cross-sectional directionally consistent replication with fasting glucose concentrations was achieved for 12 of 16 variants; 10 variants were also associated

SUBMITTER: Renstrom F 

PROVIDER: S-EPMC3012192 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature