Basal and insulin mediated VLDL-triglyceride kinetics in type 2 diabetic men.

ABSTRACT:

Objective

Increased very-low-density lipoprotein triglycerides (VLDL-TG) concentration is a central feature of diabetic dyslipidemia. The objective was to compare basal and insulin mediated VLDL-TG kinetics, oxidation, and adipose tissue storage in type 2 diabetic and healthy (nondiabetic) men.

Research design and methods

Eleven type 2 diabetic and 11 healthy men, matched for BMI and age, were included. Ex vivo-labeled VLDL-TG tracers, blood and breath samples, fat biopsies, indirect calorimetry, and body composition measures were applied to determine VLDL-TG kinetics, VLDL-TG fatty acids (FA) oxidation, and storage in regional adipose tissue before and during a hyperinsulinemic euglycaemic clamp.

Results

VLDL-TG secretion was significantly greater in diabetic compare

SUBMITTER: Sorensen LP 

PROVIDER: S-EPMC3012201 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature