MicroRNA miR-275 is indispensable for blood digestion and egg development in the mosquito Aedes aegypti.

ABSTRACT: The mosquito Aedes aegypti is the major vector of arboviral diseases, particularly of Dengue fever, of which there are more than 100 million cases annually. Mosquitoes, such as A. aegypti, serve as vectors for disease pathogens because they require vertebrate blood for their egg production. Pathogen transmission is tightly linked to repeated cycles of obligatory blood feeding and egg maturation. Thus, the understanding of mechanisms governing egg production is necessary to develop approaches that limit the spread of mosquito-borne diseases. Previous studies have identified critical roles of hormonal- and nutrition-based target of rapamycin (TOR) pathways in controlling blood-meal-mediated egg maturation in mosquitoes. In this work, we uncovered another essential regulator of blood-meal-act

SUBMITTER: Bryant B 

PROVIDER: S-EPMC3012520 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature