Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish.

ABSTRACT:

Background

Increasing use of zebrafish in drug discovery and mechanistic toxicology demands knowledge of cytochrome P450 (CYP) gene regulation and function. CYP enzymes catalyze oxidative transformation leading to activation or inactivation of many endogenous and exogenous chemicals, with consequences for normal physiology and disease processes. Many CYPs potentially have roles in developmental specification, and many chemicals that cause developmental abnormalities are substrates for CYPs. Here we identify and annotate the full suite of CYP genes in zebrafish, compare these to the human CYP gene complement, and determine the expression of CYP genes during normal development.

Results

Zebrafish have a total of 94 CYP genes, distributed among 18 gene families found also in mam

SUBMITTER: Goldstone JV 

PROVIDER: S-EPMC3012610 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature