Age and sex dependent changes in liver gene expression during the life cycle of the rat.

ABSTRACT:

Background

Age- and sex-related susceptibility to adverse drug reactions and disease is a key concern in understanding drug safety and disease progression. We hypothesize that the underlying suite of hepatic genes expressed at various life cycle stages will impact susceptibility to adverse drug reactions. Understanding the basal liver gene expression patterns is a necessary first step in addressing this hypothesis and will inform our assessments of adverse drug reactions as the liver plays a central role in drug metabolism and biotransformation. Untreated male and female F344 rats were sacrificed at 2, 5, 6, 8, 15, 21, 52, 78, and 104 weeks of age. Liver tissues were collected for histology and gene expression analysis. Whole-genome rat microarrays were used to query global express

SUBMITTER: Kwekel JC 

PROVIDER: S-EPMC3012673 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature