Maternal influences on the transmission of leukocyte gene expression profiles in population samples from Brisbane, Australia.

ABSTRACT: Two gene expression profiling studies designed to identify maternal influences on development of the neonate immune system and to address the population structure of the leukocyte transcriptome were carried out in Brisbane, Australia. In the first study, a comparison of 19 leukocyte samples obtained from mothers in the last three weeks of pregnancy with 37 umbilical cord blood samples documented differential expression of 7,382 probes at a false discovery rate of 1%, representing approximately half of the expressed transcriptome. An even larger component of the variation involving 8,432 probes, notably enriched for Vitamin E and methotrexate-responsive genes, distinguished two sets of individuals, with perfect transmission of the two profile types between each of 16 mother-child pairs in t

SUBMITTER: Mason E 

PROVIDER: S-EPMC3013110 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature