SNPs in the FCER1A gene region show no association with allergic rhinitis in a Han Chinese population.

ABSTRACT:

Background

Immunoglobulin E (IgE) is a central player in the allergic response, and raised total IgE levels are considered as an indicator of atopy or potential development of atopy. A recent genome-wide scan in a German population-based cohort of adults identified the gene encoding the alpha chain of the high affinity receptor for IgE (FCER1A) as a susceptibility locus influencing total serum IgE levels. The aim of this study was to investigate whether the polymorphisms in the FCER1A gene are associated with allergic rhinitis (AR) in a Han Chinese population.

Methodology/principal findings

A population of 378 patients with AR and 288 healthy controls was studied. Precise phenotyping of patients was accomplished by means of a questionnaire and clinical examination. Blood was

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC3013135 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature