Prediction and analysis of protein hydroxyproline and hydroxylysine.

ABSTRACT:

Background

Hydroxylation is an important post-translational modification and closely related to various diseases. Besides the biotechnology experiments, in silico prediction methods are alternative ways to identify the potential hydroxylation sites.

Methodology/principal findings

In this study, we developed a novel sequence-based method for identifying the two main types of hydroxylation sites--hydroxyproline and hydroxylysine. First, feature selection was made on three kinds of features consisting of amino acid indices (AAindex) which includes various physicochemical properties and biochemical properties of amino acids, Position-Specific Scoring Matrices (PSSM) which represent evolution information of amino acids and structural disorder of amino acids in the sliding window

SUBMITTER: Hu LL 

PROVIDER: S-EPMC3013141 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature