No Association Between Functional Polymorphisms in COMT and MTHFR and Schizophrenia Risk in Korean Population.

ABSTRACT:

Objectives

Common genetic SNPs in two genes, encoding catechol-O-methyltransferase (COMT) and methylenetetrahydrofolate reductase (MTHFR), which are interconnected with COMT gene regulation, have been reported to contribute to schizophrenia risk. In this study, we evaluated the association between functional polymorphisms in COMT and MTHFR and schizophrenia risk with a case-control study in a Korean population.

Methods

We performed a case-control study by genotyping analysis using 360 cases and 348 controls in Korean subjects to determine the association between functional polymorphisms in COMT and MTHFR and schizophrenia risk.

Results

Four functional SNPs in COMT (Val158Met and rs165599) and MTHFR (C677T and A1298C) were genotyped by primer extension assay. None of t

SUBMITTER: Kang HJ 

PROVIDER: S-EPMC3013321 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature