Nonsteroidal anti-inflammatory drugs are associated with increased neuritic plaques.

ABSTRACT:

Objectives

Observational and experimental studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) may protect against Alzheimer disease (AD); however, clinical trials and other observational studies, including the Adult Changes in Thought (ACT) study, show no protection or promotion of AD. The objective of this study is to determine the relationship between common dementia-associated pathologies and mid- to late-life NSAID exposure.

Methods

We examined the association of mid- to late-life NSAID use with neuropathologic findings on 257 autopsies from ACT, a population-based study of brain aging and incident dementia. Cumulative standard daily doses (SDD) of nonselective NSAIDs were determined from ≥10 years of computerized pharmacy dispensing data. Analyses were ad

SUBMITTER: Sonnen JA 

PROVIDER: S-EPMC3013492 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature