Cerebral microbleeds, retinopathy, and dementia: the AGES-Reykjavik Study.

ABSTRACT:

Objective

To determine whether microvascular damage, indicated by cerebral microbleeds (CMBs) and retinal microvascular signs, is associated with cognitive function and dementia in older persons.

Methods

This is a cross-sectional study of 3,906 participants (mean age 76 years; 58% women) in the AGES-Reykjavik Study (2002-2006). We assessed CMBs on MRI and retinal microvascular signs on digital retinal images. Composite Z scores of memory, processing speed, and executive function were derived from a battery of neurocognitive tests. Dementia and subtypes were diagnosed following international criteria. Regression models were used to relate cognitive Z scores and dementia to CMBs and retinal microvascular signs, adjusting for demographics, cardiovascular factors, and brain isch

SUBMITTER: Qiu C 

PROVIDER: S-EPMC3013588 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature