TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia.

ABSTRACT:

Background

We sought to describe the antemortem clinical and neuroimaging features among patients with frontotemporal lobar degeneration with TDP-43 immunoreactive inclusions (FTLD-TDP).

Methods

Subjects were recruited from a consecutive series of patients with a primary neuropathologic diagnosis of FTLD-TDP and antemortem MRI. Twenty-eight patients met entry criteria: 9 with type 1, 5 with type 2, and 10 with type 3 FTLD-TDP. Four patients had too sparse FTLD-TDP pathology to be subtyped. Clinical, neuropsychological, and neuroimaging features of these cases were reviewed. Voxel-based morphometry was used to assess regional gray matter atrophy in relation to a group of 50 cognitively normal control subjects.

Results

Clinical diagnosis varied between the groups: seman

SUBMITTER: Rohrer JD 

PROVIDER: S-EPMC3013589 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature