Does TDP-43 type confer a distinct pattern of atrophy in frontotemporal lobar degeneration?

ABSTRACT:

Objective

To determine whether TDP-43 type is associated with distinct patterns of brain atrophy on MRI in subjects with pathologically confirmed frontotemporal lobar degeneration (FTLD).

Methods

In this case-control study, we identified all subjects with a pathologic diagnosis of FTLD with TDP-43 immunoreactive inclusions (FTLD-TDP) and at least one volumetric head MRI scan (n = 42). In each case we applied published criteria for subclassification of FTLD-TDP into FTLD-TDP types 1-3. Voxel-based morphometry was used to compare subjects with each of the different FTLD-TDP types to age- and gender-matched normal controls (n = 30). We also assessed different pathologic and genetic variants within, and across, the different types.

Results

Twenty-two subjects were classif

SUBMITTER: Whitwell JL 

PROVIDER: S-EPMC3013590 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature