Ontology highlight
ABSTRACT:
SUBMITTER: Fentress SJ
PROVIDER: S-EPMC3013631 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Cell host & microbe 20101201 6
Macrophages are specialized to detect and destroy intracellular microbes and yet a number of pathogens have evolved to exploit this hostile niche. Here we demonstrate that the obligate intracellular parasite Toxoplasma gondii disarms macrophage innate clearance mechanisms by secreting a serine threonine kinase called ROP18, which binds to and phosphorylates immunity-related GTPases (IRGs). Substrate profiling of ROP18 revealed a preference for a conserved motif within switch region I of the GTPa ...[more]