TMPad: an integrated structural database for helix-packing folds in transmembrane proteins.

ABSTRACT: α-helical transmembrane (TM) proteins play an important role in many critical and diverse biological processes, and specific associations between TM helices are important determinants for membrane protein folding, dynamics and function. In order to gain insights into the above phenomena, it is necessary to investigate different types of helix-packing modes and interactions. However, such information is difficult to obtain because of the experimental impediment and a lack of a well-annotated source of helix-packing folds in TM proteins. We have developed the TMPad (TransMembrane Protein Helix-Packing Database) which addresses the above issues by integrating experimentally observed helix-helix interactions and related structural information of membrane proteins. Specifically, the TMPad offer

SUBMITTER: Lo A 

PROVIDER: S-EPMC3013749 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature