RegPhos: a system to explore the protein kinase-substrate phosphorylation network in humans.

ABSTRACT: Protein phosphorylation catalyzed by kinases plays crucial regulatory roles in intracellular signal transduction. With the increasing number of experimental phosphorylation sites that has been identified by mass spectrometry-based proteomics, the desire to explore the networks of protein kinases and substrates is motivated. Manning et al. have identified 518 human kinase genes, which provide a starting point for comprehensive analysis of protein phosphorylation networks. In this study, a knowledgebase is developed to integrate experimentally verified protein phosphorylation data and protein-protein interaction data for constructing the protein kinase-substrate phosphorylation networks in human. A total of 21,110 experimental verified phosphorylation sites within 5092 human proteins are col

SUBMITTER: Lee TY 

PROVIDER: S-EPMC3013804 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature